Abstract
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
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Acknowledgements
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03028172 to S.N.) and by the U.S. National Cancer Institute (NIH) under grant R37CA044848 and instrument grant 1 S10 OD0106400-01A1 (HR-LC-MS, both to W.F.)
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Leutou, A.S., Yang, I., Le, T.C. et al. Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis. J Antibiot 71, 609–612 (2018). https://doi.org/10.1038/s41429-018-0033-3
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DOI: https://doi.org/10.1038/s41429-018-0033-3
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