Abstract
A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-l-phenylalanyl-l-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.
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Acknowledgements
This research was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research and Development (AMED) as well as by the 24th Botanical Research Grant of the New Technology Development Foundation. We are grateful to Dr Kenichiro Nagai, Kitasato University, and Kazunari Sakai for useful suggestions concerning the experiments and collection of soil samples.
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Fukasawa, W., Mori, N., Iwatsuki, M. et al. Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981. J Antibiot 71, 682–684 (2018). https://doi.org/10.1038/s41429-018-0041-3
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DOI: https://doi.org/10.1038/s41429-018-0041-3
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