Abstract
Two new spliceostatin derivatives, designed as spliceostatin H (1) and spliceostatin I (2), and one known compound FR901464 (3), were isolated from the strain Pseudomonas sp. HS-NF-1408. Their structures were determined by the comprehensive spectroscopic data, including 1D, 2D NMR, MS spectral analysis and comparison with data from the literature. Compound 1 exhibited potent cytotoxicity activity against A549 and HepG2 with IC50 values of 3.57 and 16.72 μg/ml, respectively.
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Acknowledgements
This work was supported in part by grants from the National Natural Youth Science Foundation of China (No. 31701858), Youth innovation talent program for general undergraduate colleges of Heilongjiang Province (UNPYSCT-2017017), the Heilongjiang Postdoctoral Fund (LBH-Z17015) and the ‘Young Talents’ Project of Northeast Agricultural University (17QC14).
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Zhao, Y., Zhao, J., Lu, C. et al. Two new spliceostatin analogs from the strain Pseudomonas sp. HS-NF-1408. J Antibiot 71, 667–671 (2018). https://doi.org/10.1038/s41429-018-0052-0
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DOI: https://doi.org/10.1038/s41429-018-0052-0