Abstract
Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.
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Acknowledgements
This study was supported by funds from the Institute for Fermentation Osaka (IFO), Japan and JSPS KAKENHI (Grant Number 16H07167). We are grateful to Dr. Kenichiro Nagai and Ms. Noriko Sato, School of Pharmacy, Kitasato University for measurements of mass and NMR spectra.
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Suga, T., Kimura, T., Inahashi, Y. et al. Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. J Antibiot 71, 619–625 (2018). https://doi.org/10.1038/s41429-018-0055-x
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DOI: https://doi.org/10.1038/s41429-018-0055-x
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