Abstract
Three new cyathane diterpenes erinacines T–V (1–3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1–3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1–3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5−10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73.7 μM.
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Acknowledgements
This work was supported in part by the National Natural Science Foundation of China (21472233), the Ministry of Science and Technology of the People’s Republic of China (2014CB138304), and the Youth Innovation Promotion Association of Chinese Academy of Sciences (2014074).
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Zhang, Y., Liu, L., Bao, L. et al. Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus. J Antibiot 71, 818–821 (2018). https://doi.org/10.1038/s41429-018-0065-8
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DOI: https://doi.org/10.1038/s41429-018-0065-8
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