Abstract
Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1−5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1−5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.
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Acknowledgements
The study was supported by the Ministry of Science and High Education of Russian Federation to support the bioresource collections. The authors are grateful to the Far Eastern Center of Structural Research for performing the X-ray investigation.
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Afiyatullov, S.S., Zhuravleva, O.I., Antonov, A.S. et al. Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina. J Antibiot 71, 846–853 (2018). https://doi.org/10.1038/s41429-018-0072-9
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DOI: https://doi.org/10.1038/s41429-018-0072-9
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