Abstract
A new azaphilone derivative, named peniazaphilin A (1) and one known isocoumarin, (R)-3-methyl-6-hydroxy-8-methoxy-3,4-dihydroisocoumarin (2) were isolated from the fungus Penicillium sp. CPCC 400786. Their structures were elucidated by means of extensive spectroscopic analysis. The absolute configuration of 2 was established by circular dichroism for the first time. Compounds 1 and 2 exhibited weak anti-HIV activities with the IC50 values of 60.4 and 69.3 μM, respectively.
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Acknowledgements
The work was financially supported by the National Natural Science Foundation of China (Nos. 81402835 and 31170041), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-014), the National Infrastructure of Microbial Resources (No. NIMR-2017-3), 973 Program (No. 2012CB911102), and Beijing Municipal Science and Technology Project (Z141102004414065). Liyan Yu is supported by Xiehe Scholar.
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Zhang, D., Zhao, J., Wang, X. et al. Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786. J Antibiot 71, 905–907 (2018). https://doi.org/10.1038/s41429-018-0077-4
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DOI: https://doi.org/10.1038/s41429-018-0077-4
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