Table 1 Fractional inhibitory concentration indices of AMPs used in combination with vancomycin

From: Evaluation of LL-37 antimicrobial peptide derivatives alone and in combination with vancomycin against S. aureus

Strain

AMP

MIC of AMP

MIC of VAN

FICa

FICb

FICI

25923

LL-13

512

1

0.25

0.5

0.75

 

LL-17

512

1

0.25

0.5

0.75

 

LL-37

128

1

0.25

0.25

0.5c

43300

LL-13

256

1

0.13

0.5

0.63

 

LL-17

512

1

0.13

0.5

0.63

 

LL-37

256

1

0.5

0.5

1

700699

LL-13

1024

4

0.06

0.5

0.56

 

LL-17

1024

4

1

1

2

 

LL-37

64

4

0.25

0.5

0.75

BR-VRSA

LL-13

512

512

0.13

0.25

0.38c

 

LL-17

512

512

0.13

0.25

0.38c

 

LL-37

64

512

1

1

2

  1. AMP antimicrobial peptides, MIC minimum inhibitory concentration (µg/mL), VAN vancomycin
  2. aFIC  MIC of AMP in combination/MIC of AMP alone
  3. bFIC  MIC of vancomycin in combination/MIC of vancomycin alone
  4. cIndicates synergistic effects
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