Abstract
Neisseria meningitidis is one of the most crucial causes of bacterial meningitis worldwide. The incidence of meningitis due to N. meningitidis greatly changes from one geographical area to the other: 500,000–1,200,000 invasive meningococcal diseases occur each year, with 50,000–135,000 deaths. Once the diagnosis of bacterial meningitis is made, parenteral antibiotic treatment is started as soon as possible. A preventive treatment can also be proposed for those subjects at risk of exposure. Globally, resistance to antibiotics used in the treatment of prophylaxis of meningococcal disease is relatively rare. Penicillin is becoming less useful in the treatment of invasive meningococcal diseases because meningococcal isolates are increasingly less susceptible to this antibiotic. Meningococcal strains less susceptible to ceftriaxone or ciprofloxacin are rare. In addition, resistance to rifampicin is not a current concern as resistant isolates are rarely reported. In conclusion, the emergence of new meningococcal strains with decreasing susceptibility during the last decade should not be ignored, as this could be a worrying phenomenon in the future and justifies a judicious epidemiological survey on a continuous basis.
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References
Dwilow R, Fanella S. Invasive meningococcal disease in the 21st century-an update for the clinician. Curr Neurol Neurosci Rep. 2015;15:015–0524.
Unemo M, Shafer WM. Antimicrobial resistance in Neisseria gonorrhoeae in the 21st Century: past, evolution, and future. Clin Microbiol Rev. 2014;27:587–613. https://doi.org/10.1128/CMR.00010-14.
CLSI. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 9th edn. CLSI document M07-A9. Wayne: Clinical and Laboratory Standards Institute; 2012.
Bouba G, Nelly Michèle G, Lombart JP. Neisseria meningitidis susceptibility in North-Cameroon. Méd Mal Infect. 2014;44:443–4.
Aggarwal M, Manchanda V, Talukdar B. Meningitis due to Neisseria meningitidis serogroup B in India. Indian Pediatr. 2013;50:601–3.
Donaldson AD, Tang WY, Tan AL, Barkham T. Neisseria meningitidis with reduced susceptibility to quinolones in Singapore. J Antimicrob Chemother. 2010;65:362–4.
Bertrand S, Carion F, Wintjens R, Mathys V, Vanhoof R. Evolutionary changes in antimicrobial resistance of invasive Neisseria meningitidis isolates in Belgium from 2000 to 2010: increasing prevalence of penicillin nonsusceptibility. Antimicrob Agents Chemother. 2012;56:2268–72.
Pana M, Ghita M, Levenet I, Nica M, Botea S, Osz T. The in vitro susceptibility to 7 antibiotics of Neisseria meningitidis strains isolated last years in Romania. Roum Arch Microbiol Immunol. 2009;68:38–43.
Tapsall J. Annual report of the Australian Meningococcal Surveillance Programme, 2008. Commun Dis Intell Q Rep. 2009;33:259–67.
Lahra MM, Enriquez R. Australian Meningococcal Surveillance Programme annual report, 2016. Commun Dis Intell Q Rep. 2017;41:E369–E82.
Alemayehu T, Mekasha A, Abebe T. Nasal carriage rate and antibiotic susceptibility pattern of Neisseria meningitidis in healthy Ethiopian children and adolescents: a cross-sectional study. PLoS ONE. 2017;12:e0187207.
Zhu B, Fan Y, Xu Z, Xu L, Du P, Gao Y, et al. Genetic diversity and clonal characteristics of ciprofloxacin-resistant meningococcal strains in China. J Med Microbiol. 2014;63(Pt 11):1411–8.
Bukovski S, Vacca P, Anselmo A, Knezovic I, Fazio C, Neri A, et al. Molecular characterization of a collection of Neisseria meningitidis isolates from Croatia, June 2009 to January 2014. J Med Microbiol. 2016;65:1013–9.
Tsang RS, Law DK, Deng S, Hoang L. Ciprofloxacin-resistant Neisseria meningitidis in Canada: likely imported strains. Can J Microbiol. 2017;63:265–8.
Wu HM, Harcourt BH, Hatcher CP, Wei SC, Novak RT, Wang X, et al. Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America. N Engl J Med. 2009;360:886–92.
Sorhouet-Pereira C, Efron A, Gagetti P, Faccone D, Regueira M, Corso A, et al. Phenotypic and genotypic characteristics of Neisseria meningitidis disease-causing strains in Argentina, 2010. PLoS ONE. 2013;8:4.
Toth A, Berta B, Tirczka T, Jekkel C, Abraham A, Prohaszka Z, et al. First description of a rifampicin-resistant Neisseria meningitidis serogroup Y strain causing recurrent invasive meningococcal disease in Hungary. Acta Microbiol Immunol Hung. 2017;64:1–7.
Mounchetrou Njoya I, Deghmane A, Taha M, Isnard H, Parent, du Chatelet I. A cluster of meningococcal disease caused by rifampicin-resistant C meningococci in France, April 2012. Eur Surveill. 2012;17:34.
Gorla MC, de Paiva MV, Salgueiro VC, Lemos AP, Brandao AP, Vazquez JA, et al. Antimicrobial susceptibility of Neisseria meningitidis strains isolated from meningitis cases in Brazil from 2006 to 2008. Enferm Infecc Microbiol Clin. 2011;29:85–9.
Perez Giffoni G, Garcia Gabarrot G, Alfonso A, Pujadas M, Camou T. Detection of rifampicin-resistant strains of Neisseria meningitidis in Uruguay. Rev Panam Salud Publica. 2011;30:540–4.
Lahra MM, Enriquez RP. Australian Meningococcal Surveillance Programme annual report, 2015. Commun Dis Intell Q Rep. 2016;40:E503–E11.
CLSI. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational Supplement. CLSI document M100-S25. Wayne, PA: Clinical and Laboratory Standards Institute; 2015.
The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 8.1, 2018. http://www.eucast.org.
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Zouheir, Y., Atany, T. & Boudebouch, N. Emergence and spread of resistant N. meningitidis implicated in invasive meningococcal diseases during the past decade (2008–2017). J Antibiot 72, 185–188 (2019). https://doi.org/10.1038/s41429-018-0125-0
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DOI: https://doi.org/10.1038/s41429-018-0125-0
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