Abstract
Derivatives of the fungal depsidone, nidulin, have been synthesized in order to evaluate the potential of the chemical skeleton as antibacterial agents. Alkylation, acylation, and arylation reactions of nornidulin underwent in a regioselective manner to predominantly produce 8-O-substituted derivatives. Many of the semisynthetic derivatives showed more potent antibacterial activities than nidulin, In particular, 8-O-aryl ether derivatives displayed significant activities against Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus.
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Acknowledgements
Financial support from the Thailand Research Fund (grant No. DBG5980002) is gratefully acknowledged. We thank Professor Vatcharin Rukachaisirikul, Prince of Songkla University, for discussions and valuable suggestions on antibacterial activities of Aspergillus depsidones.
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Isaka, M., Yangchum, A., Supothina, S. et al. Semisynthesis and antibacterial activities of nidulin derivatives. J Antibiot 72, 181–184 (2019). https://doi.org/10.1038/s41429-018-0133-0
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DOI: https://doi.org/10.1038/s41429-018-0133-0
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