Abstract
In our screening program on marine-derived actinomycetes, Nonomuraea sp. AKA32 isolated from deep-sea water collected from a depth of 800 m in Sagami Bay, Japan was found to produce compounds cytotoxic to cancer cells. Activity-guided purification led to the isolation of a new aromatic polyketide, akazamicin (1), along with two known compounds, actinofuranone C (2) and N-formylanthranilic acid (3). Structures of these compounds were elucidated through the interpretation of NMR and MS spectroscopic data. Compounds 1, 2, and 3 displayed cytotoxicity against murine B16 melanoma cell line with the IC50 value of 1.7, 1.2, and 25 μM, respectively.
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We are appreciating to the Rotary Yoneyama Memorial Foundation scholarship for supporting this study.
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Yang, T., Yamada, K., Zhou, T. et al. Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp. J Antibiot 72, 202–209 (2019). https://doi.org/10.1038/s41429-018-0139-7
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DOI: https://doi.org/10.1038/s41429-018-0139-7
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