Abstract
Two new glutarimide antibiotics, 9-methylstreptimidone 2-α-d-glucopyranoside (1), and hydroxyiso-9-methylstreptimidone (2), along with a known compound, 9-methylstreptimidone (3), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. By modified Mosher’s method and acid hydrolysis, the absolute configurations of compounds 1 and 2 were established. Compounds 1 and 2 exhibited moderate cytotoxic activity.
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This work was supported in part by grants from the National Key Research and Development Program of China (No. 2017YFD0201606).
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Zhao, XL., Wang, H., Xue, ZL. et al. Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780. J Antibiot 72, 241–245 (2019). https://doi.org/10.1038/s41429-019-0143-6
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DOI: https://doi.org/10.1038/s41429-019-0143-6
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