Fig. 12
From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors
Biochemistry of BioW acyl-CoA synthetases. Pimelate (12.1) is adenylated to form a pimeloyl-AMP intermediate (12.2), which reacts with a CoA thiol nucleophile to form a pimeloyl-CoA thioester product (12.3), en route to biotin
