Fig. 2
From: The Laetiporus polyketide synthase LpaA produces a series of antifungal polyenes
Domain setup of LpaA. Domain abbreviations: β-keto synthase (KS), acyltransferase (AT), dehydratase (DH), methyltransferase (MT), enoyl reductase (ER), β-keto reductase (KR), acyl carrier protein (ACP), thioesterase (TE). Below: amino acid sequence alignments of the active site of the respective domains. Conserved residues are highlighted with vertical color-coded bars. BY1 mushroom polyene synthase PPS1 (NCBI accession #: KX819293.1); A. terreus LovF: Aspergillus terreus lovastatin diketide synthase (Q9Y7D5.1); A. solani PksN: Alternaria solani alternapyrone synthase (BAD83684.1); H. sapiens FAS: human fatty acid synthase (NP_004095.4). A MT domain is not present in the human FAS. The ER domain is inactive in LpaA and PPS1. A TE domain is not present in LovF and PksN
