Table 2 Antifungal activity of isavuconazole and comparator antifungal agents against Aspergillus spp. collected during 2011–2019 in APAC medical centers participating in the SENTRY Antifungal Surveillance Program
Species | Antifungal agent (no. tested) | MIC (µg ml−1) | ECV | |||
|---|---|---|---|---|---|---|
Range | 50% | 90% | %WT | %NWT | ||
Aspergillus spp. | Isavuconazole (126) | 0.015–4 | 0.5 | 2 | ||
Itraconazole (319) | 0.12–>8 | 0.5 | 1 | |||
Posaconazole (319) | 0.03–>8 | 0.25 | 0.5 | |||
Voriconazole (319) | 0.03–4 | 0.5 | 1 | |||
A. fumigatus | Isavuconazole (70) | 0.25–2 | 0.5 | 1 | 94.3 | 5.7 |
Itraconazole (189) | 0.25–>8 | 0.5 | 1 | 97.9 | 2.1 | |
Posaconazole (189) | 0.03–>8 | 0.25 | 0.5 | 98.9a | 1.1 | |
Voriconazole (189) | 0.06–4 | 0.5 | 0.5 | 98.9 | 1.1 | |
A. flavus SC | Isavuconazole (19) | 0.5–2 | 0.5 | 1 | 94.7 | 5.3 |
Itraconazole (43) | 0.25–1 | 0.5 | 1 | 100.0 | 0.0 | |
Posaconazole (43) | 0.12–1 | 0.25 | 0.5 | 97.7 | 2.3 | |
Voriconazole (43) | 0.12–2 | 0.5 | 1 | 100.0 | 0.0 | |
A. niger SC | Isavuconazole (18) | 0.12–4 | 2 | 4 | 100.0 | 0.0 |
Itraconazole (46) | 0.12–8 | 1 | 2 | 97.8 | 2.2 | |
Posaconazole (46) | 0.06–1 | 0.5 | 1 | 100.0 | 0.0 | |
Voriconazole (46) | 0.06–2 | 1 | 1 | 100.0 | 0.0 | |
A. terreus SC | Isavuconazole (6) | 0.06–0.5 | 0.12 | 100.0 | 0.0 | |
Itraconazole (14) | 0.25–1 | 0.5 | 1 | 100.0 | 0.0 | |
Posaconazole (14) | 0.12–0.5 | 0.25 | 0.25 | 100.0 | 0.0 | |
Voriconazole (14) | 0.06–0.5 | 0.25 | 0.5 | 100.0 | 0.0 | |
A. nidulans SC | Isavuconazole (6) | 0.015–0.25 | 0.03 | |||
Itraconazole (11) | 0.12–1 | 0.5 | 0.5 | |||
Posaconazole (11) | 0.06–0.5 | 0.25 | 0.5 | |||
Voriconazole (11) | 0.03–0.5 | 0.12 | 0.25 | |||
A. tamari | Isavuconazole (2) | 0.12–0.25 | 0.12 | |||
Itraconazole (3) | 0.25–0.5 | 0.25 | ||||
Posaconazole (3) | 0.06–0.25 | 0.12 | ||||
Voriconazole (3) | 0.12–0.5 | 0.25 | ||||
A. versicolor | Isavuconazole (1) | 0.5 | ||||
Itraconazole (3) | 0.5–1 | 0.5 | ||||
Posaconazole (3) | 0.5 | 0.5 | ||||
Voriconazole (3) | 0.25–0.5 | 0.5 | ||||
