Table 2 MICa against representative strains of biothreat bacterial pathogens

From: In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens

 

Media

B. anthracis Ames

B. pseudomallei K96243

B. mallei FMH

F. tularensis Schu4

Y. pestis CO92

GT-1

CAMHB

>128

≤0.03

16

2

2

ID-CAMHB

>128

0.06

8

2

0.25

GT-1/GT-055 (2:1)

CAMHB

>128/64

≤0.013/0.015

16/8

2

1/0.5

ID-CAMHB

>128/64

0.125/0.06

4/2

4

0.25/0.125

GT-1 + GT-055 (4 μg/ml)

CAMHB

>128/4

≤0.03/4

8/4

4/4

0.5/4

ID-CAMHB

>128/4

0.125/4

1/4

4/4

0.12/4

GT-055

CAMHB

>64

>32

>64

>32

>32

ID-CAMHB

>64

>64

64

32

>32

DOX

CAMHB

0.06

1

0.25

0.25

1

ID-CAMHB

0.5

4

0.06

≤0.015

0.5

  1. aMIC (μg/ml) of GT-1 or GT-055 or GT-1/GT-055 in combination