Table 5 Bacterial load in spleens of B. pseudomallei-infected and treated mice that survived until day 60 post-infection

From: In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens

Treatment groups

Spleen weight (g)

B. pseudomallei count (CFU/spleen)

Ceftazidime 300 mg/kg, q6

0.089

0

0.090

0

0.084

0

0.088

0

0.088

0

0.090

0

0.092

0

0.098

0

GT-1 120 mg/kg, q6, 6-hour start

0.719

1.80E + 08

GT-1/GT-055 30/30 mg/kg, q6

1.165

1.34E + 08

GT-1/GT-055 120/120 mg/kg, q6

0.099

0

0.365

0

0.355

0

GT-1/GT-055 120/120 mg/kg, q6, 6-hour start

1.889

9.50E + 08

Back to article page