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Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632

The Journal of Antibiotics volume 75, pages 199–206 (2022)Cite this article

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Abstract

Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.

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Acknowledgements

We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable guidance and suggestions. We thank Dr. K. Nagai and Ms. N. Sato (School of Pharmacy, Kitasato University) for various instrumental analyses, and Mr. T. Tokiwa for taking fungal photo and support on paper disc evaluation. This study was also partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) under Grant Numbers JP19am0101096.

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Author notes

  1. These authors contributed equally: Rima Koike, Yoshihiro Watanabe

Authors and Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan

    Rima Koike, Yoshihiro Watanabe, Kenichi Nonaka, Takuya Suga, Rei Hokari, Aki Ishiyama, Yukihiro Asami & Masato Iwatsuki

  2. Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan

    Yoshihiro Watanabe, Kenichi Nonaka, Masako Honsho, Takuya Suga, Rei Hokari, Aki Ishiyama, Yukihiro Asami & Masato Iwatsuki

  3. School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan

    Kazuho Kato, Yudai Mikasa & Kota Shimizu

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  1. Rima Koike
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  2. Yoshihiro Watanabe
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Correspondence to Masato Iwatsuki.

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Koike, R., Watanabe, Y., Kato, K. et al. Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632. J Antibiot 75, 199–206 (2022). https://doi.org/10.1038/s41429-022-00512-y

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