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New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana

The Journal of Antibiotics volume 78, pages 380–383 (2025)Cite this article

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Abstract

A new dimeric 5-hydroxy-2-hexenoic acid, clonohexenoic acid (1), a known 14-membered macrolide, acremodiol B (2), and two known benzochromenone derivatives, alternariol (3) and 2-hydroxyalternariol (4), were isolated from a culture broth of Clonostachys rogersoniana. The structures of these isolated compounds were determined using spectroscopic methods. Antimicrobial and cytotoxic activities of these compounds were then assessed. Compounds 1‒4 exhibited antimicrobial activities against Bacillus subtilis and Propionibacterium acnes. In addition, compounds 3 and 4 showed antibacterial activities against B. cereus and cytotoxic activities against three human cancer cell lines, A549, HCT-116, and Mia Paca-2.

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Acknowledgements

This research was supported by the Research Base Construction Fund Support Program funded by Jeonbuk National University in 2025. The authors thank Ms. Ji-Young Oh (Center for University-wide Research Facilities (CURF) at Jeonbuk National University) for performing NMR measurements.

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Authors and Affiliations

  1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Korea

    Dae-Cheol Choi, Dae-Won Ki, In-Kyoung Lee & Bong-Sik Yun

  2. Department of Food and Nutrition, College of Engineering, Daegu University, Gyeongsan, 38453, Republic of Korea

    Yoon Hee Kim & Min-Ju Park

  3. Department of Genetic Resources Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea

    Ji-Yul Kim

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  1. Dae-Cheol Choi
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  2. Dae-Won Ki
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  5. Ji-Yul Kim
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Correspondence to Bong-Sik Yun.

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Choi, DC., Ki, DW., Kim, Y.H. et al. New dimeric 5-hydroxy-2-hexenoic acid isolated from culture broth of Clonostachys rogersoniana. J Antibiot 78, 380–383 (2025). https://doi.org/10.1038/s41429-025-00824-9

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