Fig. 2 | The Journal of Antibiotics

Fig. 2

From: Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model

Fig. 2

Simulated concentration of lascufloxacin (LSFX) in human epithelial lining fluid (ELF) over seven days and its effect on bacterial counts of levofloxacin-susceptible and -resistant Streptococcus pneumoniae: bacterial count (a) and measured LSFX concentrations (b). The solid and dashed lines in (a) represent the trends in the bacterial counts of levofloxacin-resistant (TUM23133) and -sensitive (TUM23169) S. pneumoniae, respectively. The squares and diamonds correspond to the groups without LSFX addition, while the triangles and circles indicate the trends in bacterial counts simulated under the ELF concentrations of LSFX. The detection limit for all measurements is 100 CFU ml−1. In (b), measured LSFX concentrations for both S. pneumoniae TUM23169 (open circles) and S. pneumoniae TUM23133 (closed circles) remained below theoretical values across all sampling points

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