Table 2 New quinolones and quinolines based on hybridizing chemical motifs
From: Tuberculosis drug development; fluoroquinolone structural tailoring
No. Structure | Molecule | Strain | MIC | Evaluation technique | Cite |
|---|---|---|---|---|---|
QUINOLONES | |||||
1 |
| H37Rv | Comp. 21a = 6.9 µM Comp. 30a = 6.6 µM | Microplate Alamar Blue Assay (MABA) | [68] |
2 |
| H37Rv | Comp.11=0.2 μM | Broth Micro-dilution | [43] |
3 |
| H37Rv | 2.0 μM | Broth Micro-dilution | [44] |
4 |
| H37Rv | 0.24 µM | Resazurin microtiter assay (REMA) plate method. | [45] |
5 |
| H37Rv | 1.21 µM | Resazurin microtiter assay (REMA) plate method. | [46] |
6 |
| V4207/DS V2475/MDRa KZN494/MDRa | 9.97 μM. | MABA | [47] |
7 |
| H37Rv MDR-TB (FJ05120) XDR-TB (FJ05195) | 0.06 µg/mL 0.24 µg/mL 1.95 µg/mL | MABA | [48] |
8 |
| H37Rv | 0.9 µM | Broth Microdilution | [49] |
QUINOLINES | |||||
9a |
| H37Rv | 1,56 µg/mL | MABA | [52] |
9b |
| ||||
10 |
| H37Rv | 1,56 μg/mL | MABA | [52] |
