Table 3 Adjusted models* for mediating effects of surrogate measures of insulin sensitivity on the association between 25OHD and REE.

From: Hypothesized pathways for the association of vitamin D status and insulin sensitivity with resting energy expenditure: a cross sectional mediation analysis in Australian adults of European ancestry

Hypothesized mediator

Effect of 25OHD on hypothesized mediator

Effect of hypothesized mediator on REE

Mediating effect of hypothesized mediator on the association between 25OHD and REE

Direct effect of 25OHD on REE

Total effect of 25OHD on REE

A (SE)

p

B (SE)

p

AB (BootSE)

Bootstrap 95% CI

Ć (SE)

p

C (SE)

p

McA

0.024 (0.006)

0.0002

−88.250 (28.084)

0.002

−2.100 (0.821)

(−3.934, −0.703)

4.779 (2.239)

0.035

2.679 (2.201)

0.225

QUICKI

0.0003 (0.0001)

0.012

−2583.457 (1521.544)

0.092

−0.783 (0.534)

(−1.939, 0.134)

3.462 (2.235)

0.124

2.679 (2.201)

0.225

TYG

−0.007 (0.002)

0.0002

259.859 (91.764)

0.005

−1.935 (0.780)

(−3.679, −0.622)

4.614 (2.256)

0.043

2.679 (2.201)

0.225

  1. N = 155. Values in bold are p < 0.05
  2. *All models were adjusted for age, gender, FM, FFM, season, and waist circumference.
  3. 25OHD 25dihydroxycholecalciferol; McA McAuleys index; QUICKI Quantitative insulin insensitivity check index; TYG Triglyceride to glucose ratio.
  4. SE Standard error; CI Confidence interval; BootSE standard error obtained based on 5000 Bootstrap samples; Bootstrap 95% CI: 95% confidence interval generated based on 5000 Bootstrap samples.
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