Fig. 1
From: A clinical and molecular characterisation of CRB1-associated maculopathy
Optical coherence tomography and fundus autofluorescence imaging of patients with CRB1-associated maculopathy. a Optical coherence tomography (OCT) line scans with near infra-red reflectance images showing scan position (inset). Macro and microcystic oedema is evident in patients MEH1, 2 and BDC6. Foveolar preservation of the ellipsoid zone is present in MEH1, MEH2, Leeds 1 and BDC6. More significant degeneration has already occurred in MEH3 and 4, including loss of the external limiting membrane and outer nuclear layers. Varying degree and extent of macular thickening and loss of lamination is evident in MEH3, 4 and 5. b Fundus autofluorescence images from the same time point as OCT scans. Macular autofluorescence is abnormal in all cases, but again with a degree of foveolar sparing. In the oldest patients, the zone of abnormal autofluorecence extends to include the peripapillary retina—initially an increase in signal (Leeds 1), which is likely to evolve to reduced (MEH4) and then lost autofluorescence (MEH3 and 5)
