Table 2 Select policies for reporting individual findings from clinical genomic sequencing
From: Return of individual genomic research results: are laws and policies keeping step?
Organisation | Policy | Return approach |
|---|---|---|
ACMG | ACMG Policy Statement: Updated Recommendations Regarding Analysis and Reporting of Secondary Findings in Clinical Genome-scale Sequencing, 2015; Recommendations for Reporting of Secondary Findings in Clinical Exome and Genome Sequencing, 2017 | • Routinely inspect a panel of 59 genes deemed medically actionable to detect pathogenic variants, which may be unrelated to reasons for testing (“secondary findings”) • Expert panel updates list of genes |
ESHG | Whole-Genome Sequencing in Health Care: Recommendations of the European Society of Human Genetics, 2013 | • Use a filter to avoid unsolicited findings, or findings that cannot be interpreted • Unsolicited findings indicative of serious health problems should in principle be returned. |
CCMG | The Clinical Application of Genome-Wide Sequencing for Monogenic Diseases In Canada: Position Statement of the Canadian College of Medical Geneticists, 2015 | • Use a filter to avoid incidental findings • Incidental findings that reveal risk for a highly penetrant condition medically actionable during childhood should be reported to the parents. |
