Fig. 3: Pathways involved in Macular Degeneration/Dystrophy pathogenesis.
From: Whole exome sequencing reveals putatively novel associations in retinopathies and drusen formation
The genetics of MD/dystrophy can be broken into three biological processes: (1) ECM homeostasis and remodeling (2) Lipid metabolism (3) Complement system. Proteins implicated in macular dystrophies or MD are highlighted in blue. LRP1 (red) through interaction with known proteins, provides a fascinating bridge between these three processes. Adapted from Kortvely and Ueffing [36].
