Fig. 1: Germline variants were significantly enriched in COVID-19 patients with severe cytokine storms.

A The red, blue, and green lines represent the receiver operating characteristic (ROC) curves of IP-10, IL-Ra, or MCP-3 to discriminate COVID-19 patients with ICU admission or without ICU admission, respectively. The areas under the curve (AUC) and the optimal cutoff values set by Youden’s index are shown in the graph. B The bar chart shows the mutation percentage of the four genes in high- and low-level cytokine groups and in Chinese population from 1000 G. The statistically significant mutation burden was analyzed by the chi-square test and the Fisher’s test. *P < 0.05; **P < 0.01. C The stacked bar shows the total percentage of patients harboring UNC13D or AP3B1 variants. The patients were grouped according to the severity of cytokine storms, COVID-19 severity, ICU admission, and fatal outcomes. The statistical significance between the groups was assessed by the chi-square test. *P < 0.05; **P < 0.01; ***P < 0.001.