Fig. 1: Simplified gene diagram representing the canonical transcript of P4HTM, Refseq NM_177938.2.

The proband’s compound heterozygous variants are shown in bold with filled triangles (red). Previously reported variants are shown with unfilled triangles. All variants were rare or absent in population databases and predicted to result in loss of function of P4HTM. The numbers represent amino acid position. TMD transmembrane domain.