Fig. 5: Stratification of heritability by tissue.
From: Gene-lifestyle interactions in the genomics of human complex traits
Cell-type partitioned heritability for each exposure was performed and further merged into nine primary tissue categories. The top panels show the results for lipids: LDL (a), HDL (b), and TG (c), and the bottom panels show the results for blood pressure: DBP (d), and SBP (e). For each phenotype-exposure pair we derived the difference in enrichment defined as the median enrichment in unexposed minus the median enrichment in exposed individuals (Δenrichment) per tissue. To highlight the significance of enrichment within each cell type, we scaled the size of each data point by the proportion of cell types that are nominally significant (i.e., P < 0.05) after merging exposed and unexposed results.
