Table 1 Summary of trans-ancestry GWIS results for 2df joint and 1df interaction tests.

From: Gene-lifestyle interactions in the genomics of human complex traits

Outcome		Exposure	# variants	Sample size^a (disc)	Sample size^a (rep)	# Loci (signals)^b 2df	# loci (signals)^b 1df
Lipids	HDL	Current drinking	7,505,310	127,252	231,043	111 (584)	0 (0)
		Drinking habits	6,848,811	118,899	217,468	109 (528)	0 (0)
		Current smoking	6,306,314	133,508	253,467	69 (335)	0 (0)
		Ever smoking	7,269,995	133,816	251,711	74 (370)	0 (0)
	LDL	Current drinking	7,448,913	118,654	171,142	92 (492)	0 (0)
		Drinking habits	6,834,699	111,093	155,280	78 (446)	0 (0)
		Current smoking	6,261,354	125,629	188,109	53 (251)	0 (0)
		Ever smoking	7,251,615	125,638	186,230	45 (163)	0 (0)
	TG	Current drinking	7,410,534	104,716	221,722	71 (413)	0 (0)
		Drinking habits	6,839,760	103,214	210,623	72 (365)	0 (0)
		Current smoking	7,122,377	111,900	241,140	52 (220)	0 (0)
		Ever smoking	8,438,564	111,909	238,972	49 (226)	0 (0)
Blood pressure	SBP	Current drinking	7,489,960	121,948	426,121	55 (106)	0 (0)
		Drinking habits	10,639,279	62,479	114,058	29 (47)	0 (0)
		Current smoking	6,849,695	127,730	474,475	66 (139)	0 (0)
		Ever smoking	7,928,860	127,733	458,034	68 (137)	0 (0)
	DBP	Current drinking	7,490,269	121,947	426,177	57 (101)	0 (0)
		Drinking habits	10,639,829	62,479	114,111	31 (42)	0 (0)
		Current Smoking	6,784,799	127,730	474,531	70 (138)	0 (0)
		Ever smoking	7,930,829	127,730	458,089	66 (136)	0 (0)
	MAP	Current drinking	7,489,903	121,947	426,112	48 (71)	0 (0)
		Drinking habits	10,639,231	62,479	113,287	32 (46)	0 (0)
		Current smoking	6,848,964	127,730	474,465	69 (144)	1 (1)
		Ever smoking	7,932,503	127,730	458,024	67 (137)	0 (0)
	PP	Current drinking	7,489,921	121,947	420,767	39 (67)	0 (0)
		Drinking habits	10,639,279	62,479	114,111	18 (27)	0 (0)
		Current smoking	7,934,402	127,730	473,514	54 (92)	0 (0)
		Ever smoking	7,934,402	127,730	457,073	54 (90)	0 (0)

HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, PP pulse pressure, 1df 1 degree of freedom interaction test, 2df 2 degrees of freedom joint test, disc Discovery stage, rep replication stage.
^aMaximum sample size across all variants analyzed.
^bPlain text number corresponds to the count of associated loci (region of 1 Mb or more harboring at least one GWAS hit), while the number of independent association signals (associated SNPs remaining after clumping) is provided in parenthesis.

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Table 1 Summary of trans-ancestry GWIS results for 2df joint and 1df interaction tests.

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