Table 2 Association signal overlap between the 2df joint test (accounting for interactions) and previous GWAS of marginal genetic effect.

From: Gene-lifestyle interactions in the genomics of human complex traits

Phenotype

Overall

CHARGE only, per exposure

External GWAS only

Both

CHARGE only

Current drinking

Drinking habits

Current smoking

Ever smoking

HDL

70

83

21

18

17

11

11

LDL

60

63

30

25

17

6

6

TG

91

57

15

9

11

6

5

SBP

33

37

35

21

6

27

28

DBP

47

46

26

16

4

22

17

All

301

286

127

89

55

72

67

  1. HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, 1df 1 degree of freedom interaction test, 2df 2 degrees of freedom joint test, disc discovery stage, rep replication stage.
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