Table 2 Assessment of genetic-specific psychosocial difficulties by counselees and by clinicians.

From: Assessment of psychosocial difficulties by genetic clinicians and distress in women at high risk of breast cancer: a prospective study

PAHC domainsa

Counselees’ responses “Quite a bit”/“Very much”

Clinicians’ responses “Minor”/“Important”

Agreement rate b (true positives and negatives)

Underestimationb (false negatives)

Overestimationb (false positives)

Agreement level Kappa (95% CI)

Hereditary predisposition

388 (55.0)

335 (50.0)

377 (56.5)

164 (24.6)

126 (18.9)

0.13 (0.05–0.21)

 Sample 1 (FR1)

113 (53.1)

82 (41.6)

112 (56.9)

55 (27.9)

30 (15.2)

0.15 (0.02–0.28)

 Sample 2 (SP)

86 (65.2)

51 (38.4)

78 (59.1)

45 (34.1)

9 (6.8)

0.24 (0.10–0.38)

 Sample 3 (FR2)

89 (57.1)

66 (42.3)

91 (58.7)

43 (27.7)

21 (13.5)

0.19 (0.05–0.34)

 Sample 4 (GE)

100 (48.8)

136 (73.9)

96 (52.5)

21 (11.5)

66 (36.1)

0.06 (−0.07–0.18)

Practical issues

218 (30.9)

228 (34.0)

373 (56.0)

137 (20.6)

156 (23.4)

0.001 (−0.08–0.08)

 Sample 1 (FR1)

79 (37.1)

32 (16.2)

118 (59.6)

60 (30.3)

20 (10.1)

0.01 (−0.11–0.13)

 Sample 2 (SP)

59 (45.4)

36 (27.1)

78 (60.0)

38 (29.2)

14 (10.8)

0.16 (0.01–0.32)

 Sample 3 (FR2)

45 (28.8)

54 (34.8)

92 (59.7)

26 (16.9)

36 (23.4)

0.08 (−0.08–0.24)

 Sample 4 (GE)

35 (17.0)

106 (57.6)

85 (46.2)

13 (7.1)

86 (46.7)

0.02 (−0.08–0.12)

Familial issues

399 (56.7)

304(45.4)

340 (51.1)

202 (30.4)

123 (18.5)

0.04 (−0.04–0.11)

 Sample 1 (FR1)

145 (68.7)

73 (37.1)

101 (51.8)

78 (40.0)

16 (8.2)

0.12 (0.01–0.23)

 Sample 2 (SP)

79 (60.3)

58 (43.6)

70 (53.4)

42 (32.1)

19 (14.5)

0.10 −0.06–0.26

 Sample 3 (FR2)

103 (66.0)

54 (34.6)

83 (53.6)

60 (38.7)

12 (7.7)

0.15 (0.03–0.28)

 Sample 4 (GE)

72 (35.0)

119 (64.7)

86 (46.7)

22 (12.0)

76 (41.3)

0.02 (−0.10–0.14)

Emotions

288 (40.9)

220 (47.7)

393 (59.0)

116 (17.4)

157 (23.6)

0.17 (0.09–0.25)

 Sample 1 (FR1)

96 (45.5)

69 (34.8)

127 (64.8)

46 (23.5)

23 (11.7)

0.28 (0.15–0.41)

 Sample 2 (SP)

52 (39.7)

62 (46.6)

78 (59.5)

22 (16.8)

31 (23.7)

0.18 (0.01–0.35)

 Sample 3 (FR2)

75 (48.1)

75 (48.1)

100 (64.5)

27 (17.4)

28 (18.1)

0.29 (0.14–0.44)

 Sample 4 (GE)

65 (31.6)

114 (62.0)

88 (47.8)

21 (11.4)

75 (40.8)

0.04 (−0.08–0.16)

Living with cancer

643 (91.5)

355 (53.1)

349 (52.7)

284 (42.9)

29 (4.4)

0.002 (−0.04–0.05)

 Sample 1 (FR1)

197 (93.4)

83 (42.3)

85 (43.8)

105 (54.1)

4 (2.1)

0.02 (−0.04–0.08)

 Sample 2 (SP)

129 (98.5)

63 (47.4)

62 (47.3)

68 (51.9)

1 (0.8)

−0.002 (−0.04–0.04)

 Sample 3 (FR2)

133 (85.8)

67 (43.2)

73 (47.7)

72 (47.1)

8 (5.2)

0.04 (−0.06–0.14)

 Sample 4 (GE)

184 (89.3)

142 (77.2)

129 (70.1)

39 (21.2)

16 (8.7)

−0.05 (−0.17–0.06)

Children-related issues

369 (70.6)

285 (47.1)

245 (51.5)

172 (36.1)

59 (12.4)

0.04 (−0.04–0.12)

 Sample 1 (FR1)

142 (78.9)

81 (46.6)

83 (52.2)

63 (39.6)

13 (8.2)

0.06 (−0.06–0.18)

 Sample 2 (SP)

92 (92.0)

49 (37.7)

45 (45.0)

53 (53.0)

2 (2.0)

0.05 (−0.04–0.13)

 Sample 3 (FR2)

63 (63.6)

35 (29.4)

55 (61.1)

31 (34.4)

4 (4.4)

0.29 (−0.13–0.44)

 Sample 4 (GE)

72 (50.0)

120 (65.9)

62 (48.8)

25 (19.7)

40 (31.5)

−0.04 (−0.21–0.13)

  1. Table entries are number (%) of counselees, except column of concordance level.
  2. CI confidence interval.
  3. aGenetic-specific difficulties assessed with the Psychosocial Aspects in Hereditary Cancer (PAHC) questionnaire covering six domains of difficulties.
  4. bAgreement, under- and overestimation based on data available for both counselees and clinicians.
Back to article page