Fig. 1: Family trees of the four sequenced individuals (I-IV) with diabetes that represent two sibling-pairs.

Males are represented using squares and females by circles; a diagonal line indicates deceased individuals. Black filled symbols correspond to individuals with type 2 diabetes (DM). Data under the symbols represent the mutation carrier status (N = Normal allele, M = Mutation) and the age at diagnosis of diabetes (available only for the four sequenced individuals). The mutation status for the parents of individuals I-IV was inferred using IBD sharing on chromosome X.