Fig. 1: Data filtering workflow for cases and Orphanet data.

A Filtering of cases from data freeze 1 cohort extraction, definition of the initial population by redefining solved and unsolved cases. Obtention of the final study population after exclusion of cases with no HPO annotation. B Filtering of clinical entities of Orphanet database for active clinical entities, preparation of the final reference data (ORPHAcodes).