Table 1 Characteristics of 45,061 participants included in the analysis.

From: Sociodemographic and health factors associated with genetic testing in Australia: insights from a cohort-based study of 45,061 participants

Characteristicsa

No. of participants

% of all participants

Age at 2020 follow-up (median age: 70 years; interquartile range: 64–76 years)

 56–59 years

3403

7.6%

 60–69

19,079

42.3%

 70–79

15,603

34.6%

 80+

6976

15.5%

Sex

 Male

19,848

44.0%

 Female

25,213

56.0%

Education: highest educational qualification, reported on individual level at cohort recruitmentb

 No school certificate or other qualifications/School or intermediate certificate

10,377

23.0%

 Higher school or leaving certificate

4010

8.9%

 Trade/apprenticeship

3953

8.8%

 Certificate/diploma

10,898

24.2%

 University degree or higher

15,430

34.2%

 Unknown/no response

393

0.9%

Household income: annual pre-tax income, reported on household level ($AUD)

 <$30,000

9649

21.4%

 $30,000–<$50,000

7744

17.2%

 $50,000–<$90,000

11,172

24.8%

 $90,000+

9605

21.3%

 Unknown/Prefer not to answer

6891

15.3%

Health insurance status

 Medicare only (including those with no private health insurance, no healthcare concession card, and no Department of Veterans’ Affairs White or Gold Card)

5049

11.2%

 Healthcare concession card

6458

14.3%

 Department of Veterans’ Affairs healthcare coverage (White or Gold card)

657

1.5%

 Private health insurance (with/without extras)

32,897

73.0%

Area-based socioeconomic status: quintile of index of relative socioeconomic disadvantage, based on place of residence on area level [11]

 Most disadvantaged

7190

16.0%

 Quintile 2

8696

19.3%

 Quintile 3

8282

18.4%

 Quintile 4

8278

18.4%

 Least disadvantaged

10,447

23.2%

 Missing

2168

4.8%

Accessibility/Remoteness of place of residence: based on place of residence on area level [19]

 Major cities

22,387

49.7%

 Inner regional

16,176

35.9%

 Outer regional

4405

9.8%

 Remote/Very Remote

333

0.7%

 Missing

1760

3.9%

Personal history of invasive cancer diagnosis in 1994–2019: based on NSW Cancer Registry linked datac

 Cancer diagnosis

7916

17.6%

 No cancer diagnosis

37,145

82.4%

Detailed personal history of cancer diagnosis in 1994–2019: based on NSW Cancer Registry linked data, for n = 7916 participants with record of invasive cancer diagnosisc

 Breast cancer (ICD-10 code C50)

1717

3.8%

 Colorectal cancer (ICD-10 code C18-20)

932

2.1%

 Lung cancer (ICD-10 code C33-34)

133

0.3%

 Melanoma (ICD-10 code C43)

1550

3.4%

 Prostate cancer (ICD-10 code C61)

2376

5.3%

 Other cancer (ICD-10 code C00-97, excluding C18-20, C33-34, C43, C50, and C61)

2013

4.5%

Personal history of other health conditions: based on self-report

 Cardiovascular disease (incl. heart failure, atrial fibrillation, blood clots, other heart disease and stroke)

11,497

25.5%

 Diabetes (Type 1/Type 2 or unsure)

4731

10.5%

Family history of cancer: related to mother, father, and/or sibling(s), blood relatives only

Any cancer

24,182

53.7%

 Breast cancer

6721

14.9%

 Colorectal cancer

7738

17.2%

 Lung cancer

5608

12.4%

 Melanoma

5908

13.1%

 Ovarian cancer

1493

3.3%

 Prostate cancer

6635

14.7%

Family history of non-cancer conditions: related to mother, father, and/or sibling(s), blood relatives only

 Heart disease

23,260

51.6%

 Stroke

13,318

29.6%

 Dementia /Alzheimer’s

12,292

27.3%

 Diabetes

11,151

24.7%

Ever having children: based on number of children ever given birth to/fathered, reported at cohort recruitmentb

 Yes (1+ children given birth to/fathered)

39,176

86.9%

 No

5885

13.1%

  1. All 45 and Up Study questionnaires and data books (including the baseline questionnaire and 2020 follow-up questionnaire) can be accessed from the Sax Institute (https://www.saxinstitute.org.au/solutions/45-and-up-study/use-the-45-and-up-study/data-and-technical-information, accessed 11 October 2024).
  2. aInformation was based on the 2020 follow-up questionnaire unless specified otherwise. For all characteristics based on questionnaire data, “missing” was included as a separate category in regression analyses.
  3. bThese characteristics were based on the baseline questionnaire [9, 10].
  4. cDetermined based on all records of invasive cancer (excluding keratinocyte/non-melanoma skin cancers) in the NSW Cancer Registry, including cancer type and year of diagnosis. ICD-10-codes are provided in parentheses. Due to the relatively small number of cases (n = 70), ovarian cancer was included in the “Other cancer” group.