Fig. 3: Reclassification of VUS subclasses according to ClinGen FBN1-specific guideline with new PP1/PP4 criteria.

LBV likely benign variant, LPV likely pathogenic variant, PV pathogenic variant, VUS variant of uncertain significance, VUS-H variant of uncertain significance-high subclass, VUS-L variant of uncertain significance-low subclass, VUS-M variant of uncertain significance-mid subclass, VUS-U variant of uncertain significance-unsubclassified.