Fig. 5 | Gene Therapy

Fig. 5

From: Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

Fig. 5

Immunohistochemical NIS staining. Paraffin embedded tumor sections were immunohistochemically stained for NIS expression. Tumors from mice treated with polyplexes for dual-targeting revealed clusters of membrane-associated as well as cytoplasmatic NIS gene expression around blood vessels in the tumorous tissue. Animals that were injected with polyplexes for single EGFR- and cMET-targeting showed NIS-specific immunoreactivity as well that correlated with PET imaging data

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