Fig. 7 | Gene Therapy

Fig. 7

From: Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

Fig. 7

Perfusion of intrahepatic tumors determined by CEUS. Tumors of mice treated with polyplexes for dual-targeting that received 55.5 MBq 131I (n = 4) demonstrated an overall reduced contrast agent uptake expressed in arbitrary units (a.u.) compared to mice that received saline instead (a) (n = 3). Further, tumors of therapy mice showed reduced peak enhancement (PE 1432.7 ± 534.6 (b)), wash-in area under the curve (WiAUC 7184.2 ± 2197.6 (c)) and retention time (RT 7.98 ± 0.97 (d)) after radioiodide therapy as compared to control animals (PE: 2425.9 ± 260.5; WiAUC: 19633.4 ± 1451.8; RT: 11.39 ± 0.71 (b–d)). Results are expressed as mean ± SEM (*p ≤ 0.05; **p ≤ 0.01)

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