Fig. 5 | Gene Therapy

Fig. 5

From: Bat adeno-associated viruses as gene therapy vectors with the potential to evade human neutralizing antibodies

Fig. 5

Roadmap (a) and spatial localization (b) of positively selected sites in bat AAV capsid genes on the exterior surface of AAV2 capsids. The two selected residues are displayed in blue, corresponding to V259 and N691 in bat AAV 10HB capsid, or H271 and N705 in AAV2 capsid. The axes of symmetry are shown by solid pentagon (five-fold), triangle (three-fold), and oval (two-fold) on the AAV2 capsid structure

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