Fig. 5: rClone30-Anh(F) upregulated the autophagy-related genes. | Gene Therapy

Fig. 5: rClone30-Anh(F) upregulated the autophagy-related genes.

From: RETRACTED ARTICLE: Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses

Fig. 5

a The breast cancer cells MDA-MB-231 infected with rClone30 or rClone30-Anh(F) were harvested to carried out transcriptome analysis, and form a heat map of genes comprising apoptosis and autophagy. b The MDA-MB-231 cells infected with recombinant viruses were collected and total RNA were extracted. The mRNA transcription level of caspase-3, Bax, Bcl2, ATG5, Beclin 1, and LC3B were measured by Real-time PCR. Data represent mean ± SEM of triplicate samples (#P < 0.05, ##P < 0.01,compared with rClone30 group).

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