Table 3 AAV1/SERCA2a vector DNA presence in the heart by qPCR.

From: Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL

Subj.

Treatment

AAV NaB Strata

Source

Sample

AAV1/SERCA2a DNA Conc.a

3

AAV1/SERCA2a

−ve

Basal Interior Wall

EM Biopsy

38.0

Basal Interior Wall

EM Biopsy

BLOD

Lateral Wall

EM Biopsy

BLOD

Lateral Wall

EM Biopsy

BLOD

3

AAV1/SERCA2a

−ve

Anterior Septum

Transplant

BLOD

Anterior Wall

Transplant

BLOD

Posterior Septum

Transplant

BLOD

Posterior Wall

Transplant

BLOD

5

AAV1/SERCA2a

−ve

Anterior Septum

Transplant

80.0

Anterior Wall

Transplant

41.1

Posterior Septum

Transplant

56.7

Posterior Wall

Transplant

23.1

  1. BLOD below limit of detection.
  2. ass DNA copy numbers/µg human gDNA.