Table 1 Percentage of body weight and body length when compared to wildtype mice at corresponding sex and age.
From: First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model
Percentage of normal wildtype as 100% (at 16-week post AAV injection or equivalent to 20 to 21-week-old of mice age) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Uninjected control | AAV8 dose: 4 × 1010 vg/mouse | |||||||||
GHR+/+ | GHR+/− | GHR−/− | AAV8-HLP-Luc | AAV8-HLP-mGHR | ||||||
Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | |
Male | ||||||||||
Body weight | 100.0 | 2.3 | 94.6 | 2.9 | 42.9 | 1.2 | 47.7 | 2.6 | 59.5* | 3.3 |
Body length | 100.0 | 1.0 | 98.9 | 1.0 | 73.3 | 0.5 | 73.0 | 0.9 | 78.7*** | 0.8 |
Female | ||||||||||
Body weight | 100.0 | 1.2 | 89.9 | 2.4 | 50.1 | 2.7 | 54.8 | 4.1 | 65.6n.s. | 4.6 |
Body length | 100.0 | 1.1 | 98.0 | 0.9 | 73.7 | 0.6 | 76.0 | 0.9 | 81.1* | 1.5 |
