Table 1 Locus-level heterogeneity between multiple sclerosis patients and controls

From: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis

Locus

χ 2

d.f.

p-value

Significancea

A

43.3012

17

4.34E−04

*

A~DRB1

169.5478

38

<2.22E−16

*

A~DRB1~DQB1

161.7085

39

<2.22E−16

*

A~C~B~DRB1~DQB1~DPB1

42.5118

11

1.3205E−05

*

C~B

81.8819

33

4.9007E−06

*

C~B~DRB1

100.52

24

2.45E−11

*

DRB1~DQB1

159.1034

26

<2.22E−16

*

DPB1

21.061

15

1.35E−01

NS

  1. χ2 chi-squared value, d.f. degrees of freedom, NS not significant
  2. Significant p-values are indicated with asterisks
  3. aAfter correcting for eight comparisons, significance was evaluated at the 6.25E−03 level
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