Table 2 Significant association of DRB1~DQB1 haplotypes and DPB1 alleles with multiple sclerosis

From: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis

Locus

Allele

Controls (N)

Patients (N)

OR

95% CI lower

95% CI upper

p-value

Significancea

DRB1~DQB1

01:01~05:01

84

36

0.41

0.27

0.63

9.5866E−06

*

DRB1~DQB1

03:01~02:01

79

119

1.63

1.19

2.24

0.0014115

*

DRB1~DQB1

04:01~03:01

42

17

0.4

0.21

0.73

0.0012401

*

DRB1~DQB1

07:01~02:02

86

49

0.56

0.38

0.81

0.001417

*

DRB1~DQB1

11:01~03:01

58

38

0.65

0.42

1.01

0.0462

*

DRB1~DQB1

14:01~05:03

19

8

0.42

0.16

1.02

0.037742

*

DRB1~DQB1

15:01~06:02

79

240

3.98

3

5.31

<2.22e−16

*

  1. Binned: Alleles with expected counts less than five in cases or controls were combined into a common “binned” category for analysis, as described in the “Tests of Association” section. Results for all comparisons are included in Supplementary Table S1. Counts and frequencies for all detected alleles and haplotypes are included in Supplementary Table S2
  2. OR odds ratio, CI confidence interval
  3. p-values were not corrected for loci that displayed significant locus-level heterogeneity. p-values for loci that did not display significant locus-level heterogeneity were corrected for the number of analyzed categories; for the DPB1 locus, significance was evaluated at the 0.003125 level, and no DPB1 alleles displayed a significant association. Significant p-values are indicated with asterisks
  4. a For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 1
  5. Haplotypes identified as NA (Not Applicable) were included in the Binned category, and are shown only for purposes of comparison
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