Table 4 Association of HLA-A*02:01 and C*03:04~B*40:01 with multiple sclerosis in the presence and absence of DRB1*15:01

From: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis

Locus

Haplotype

Controls (N)

Patients (N)

OR

95% CI lower

95%CI upper

p-value

Significancea

A~C~B

02:01~03:04~40:01

26

4

0.15

0.04

0.45

6.51E−05

*

A~C~B

02:01~XXXX~XXXX

197

160

0.79

0.62

1.01

4.78E−02

*

A~C~B

YYYY~03:04~40:01

24

10

0.42

0.18

0.92

1.82E−02

*

C~B~DRB1

03:04~40:01~WWWW

47

14

0.29

0.15

0.55

2.45E−05

*

C~B~DRB1

ZZZZ~ZZZZ~15:01

85

253

3.95

3.00

5.23

1.24E−25

*

A~DRB1

02:01~15:01

21

56

2.85

1.68

5.01

2.885E−05

*

A~DRB1

02:01~UUUU

202

108

0.48

0.37

0.62

1.13E−08

*

A~DRB1

VVVV~15:01

65

197

3.76

2.77

5.15

1.09E−19

*

  1. UUUU: Any DRB1 allele other than DRB1*15:01
  2. VVVV: Any HLA-A allele other than A*02:01
  3. WWWW: Any DRB1 allele (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
  4. XXXX~XXXX: Any C~B haplotype other than C*03:04~B*04:01
  5. YYYY: Any HLA-A allele other than A*02:01
  6. ZZZZ~ZZZZ: Any C~B haplotype (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
  7. OR odds ratio, CI confidence interval
  8. p-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks
  9. a For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 1
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