Table 5 Association of specific A~C~B~DRB1*15:01~DQB1~DPB1 haplotypes with multiple sclerosis

From: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis

Locus

Haplotypea

Controls (N)

Patients (N)

OR

95% CI lower

95% CI upper

p-value

Significanceb

A~C~B~DRB1~DQB1~DPB1

02:01~07:02~07:02~15:01~06:02~04:01

10

16

1.65

0.7

4.09

2.14E−01

NS

A~C~B~DRB1~DQB1~DPB1

03:01~07:02~07:02~15:01~06:02~04:01

20

53

2.83

1.64

5.04

5.22E−05

*

A~C~B~DRB1~DQB1~DPB1

24:02~07:02~07:02~15:01~06:02~04:01

3

13

4.48

1.22

24.6

1.06E−02

*

  1. OR odds ratio, CI confidence interval, NS not significant
  2. p-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks
  3. a HLA-A alleles encoding the A3/A11 KIR ligand, HLA-C alleles encoding the C1 KIR ligand (none shown) and HLA-B alleles encoding the Bw4 KIR ligand are indicated in bold
  4. b For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 1
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