Table 6 Association of DRB1~DQB1 genotypes in the presence and absence of HLA-A*02:01 and C~B genotypes in the presence and absence of DRB1*15:01 with multiple sclerosis

From: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis

Locus

Genotype

Controls (N)

Cases (N)

OR

95% CI lower

95% CI upper

p-value

Significancea

C~B~DRB1

03:04~40:01~UUUU+VVVV~VVVV~DRB1*15:01

6

8

1.37

0.41

4.83

5.68E−01

NS

C~B~DRB1

WWWW~WWWW~UUUU+VVVV~VVVV~DRB1*15:01

75

215

5.06

3.65

7.04

3.21E−13

*

A~DRB1~DQB1

02:01~15:01~06:02+02:01~YYYY~YYYY

5

9

1.86

0.55

7.12

2.63E−01

NS

A~DRB1~DQB1

02:01~15:01~06:02+XXXX~YYYY~YYYY

17

36

2.28

1.22

4.40

5.45E−03

*

A~DRB1~DQB1

02:01~YYYY~YYYY+02:01~YYYY~YYYY

16

7

0.44

0.15

1.14

6.42E−02

NS

A~DRB1~DQB1

02:01~YYYY~YYYY+XXXX~15:01~06:02

14

26

1.96

0.97

4.12

4.39E−02

*

A~DRB1~DQB1

02:01~YYYY~YYYY+XXXX~YYYY~YYYY

147

55

0.29

0.20

0.41

3.70E−13

*

A~DRB1~DQB1

XXXX~15:01~06:02+XXXX~15:01~06:02

2

22

11.82

2.87

104.21

2.70E−05

*

A~DRB1~DQB1

XXXX~15:01~06:02+XXXX~YYYY~YYYY

35

111

4.07

2.67

6.32

1.50E−12

*

  1. OR odds ratio, CI confidence interval, NS not significant
  2. UUUU: Any DRB1 allele (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
  3. VVVV~VVVV: Any C~B haplotype (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
  4. WWWW~WWWW: Any non-C*03:04~B*40:01 haplotype.
  5. XXXX: Any non-A*02:01 allele
  6. YYYY~YYYY: Any non-DRB1*15:01~DQB1*06:02 haplotype
  7. The p-value of locus-level heterogeneity for C~B~DRB1 genotype evaluations is 7.07E−25, and that of locus-level heterogeneity for A~DRB1~DQB1 genotype evaluations is 3.50E−23. p-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks
  8. a For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity
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