Table 2 Association between one or more children histocompatible from the mother’s perspective among rheumatoid arthritis (RA) cases compared to controls (analyses are for each HLA locus and are adjusted for number of live births)
Any histocompatible children | RA n (%) | Controls n (%) | OR (95% CI) | Bonferroni corrected p valuea |
|---|---|---|---|---|
HLA Class I | ||||
A | ||||
None | 104 (75) | 683 (75) | Reference | |
1 or more | 34 (25) | 230 (25) | 1.0 (0.6–1.5) | 1.00 |
B | ||||
None | 111 (80) | 814 (89) | Reference | |
1 or more | 27 (20) | 99 (11) | 1.9 (1.2–3.1) | 0.04 |
C | ||||
None | 105 (76) | 752 (82) | Reference | |
1 or more | 33 (24) | 161 (18) | 1.4 (0.9–2.2) | 0.77 |
HLA Class II | ||||
DPB1 | ||||
None | 63 (46) | 555 (61) | Reference | |
1 or more | 75 (54) | 358 (39) | 1.8 (1.2–2.6) | 0.01 |
DQA1 | ||||
None | 74 (54) | 597 (65) | Reference | |
1 or more | 64 (46) | 316 (35) | 1.6 (1.1–2.3) | 0.10 |
DQB1 | ||||
None | 93 (67) | 725 (79) | Reference | |
1 or more | 45 (33) | 188 (21) | 1.8 (1.2–2.7) | 0.03 |
DRB1 | ||||
None | 103 (75) | 765 (84) | Reference | |
1 or more | 35 (25) | 148 (16) | 1.6 (1.0–2.4) | 0.28 |
