Table 4 Mean sequence similarity matching (SSM) score and risk of rheumatoid arthritis (RA) among mothers
Histocompatibility per SSM score (Quartile) | RA n (%) | Controls n (%) | OR (95% CI)a | p for linear trend |
|---|---|---|---|---|
HLA Class I | ||||
A | ||||
Least (4th) | 30 (22) | 222 (24) | Reference | |
Most (1st) | 35 (25) | 229 (25) | 1.2 (0.7–2.0) | 0.35 |
B | ||||
Least (4th) | 37 (27) | 231 (25) | Reference | |
Most (1st) | 34 (25) | 231 (25) | 1.0 (0.6–1.6) | 0.99 |
C | ||||
Least (4th) | 35 (25) | 209 (23) | Reference | |
Most (1st) | 32 (23) | 227 (25) | 0.8 (0.5–1.4) | 0.52 |
HLA Class II | ||||
DPB1 | ||||
Least (4th) | 24 (17) | 220 (24) | Reference | |
Most (1st) | 42 (30) | 244 (27) | 1.5 (0.9–2.6) | 0.26 |
DQA1 | ||||
Least (4th) | 22 (16) | 218 (24) | Reference | |
Most (1st) | 24 (17) | 221 (24) | 1.1 (0.6–2.0) | 0.65 |
DQB1 | ||||
Least (4th) | 28 (20) | 295 (32) | Reference | |
Most (1st) | 33 (24) | 221 (24) | 1.6 (0.9–2.8) | 0.04 |
DRB1 | ||||
Least (4th) | 23 (17) | 210 (23) | Reference | |
Most (1st) | 34 (25) | 244 (27) | 1.3 (0.7–2.3) | 0.65 |
