Table 5 Mother−child similarity score—Mean sequence similarity matching (SSM) score and risk of systemic lupus erythematosus (SLE) among mothers
Histocompatibility per SSM score (Quartile) | SLE n (%) | Controls n (%) | OR (95% CI)a | p for linear trend |
---|---|---|---|---|
HLA Class I | ||||
A | ||||
Least (4th) | 26 (22) | 222 (24) | Reference | |
Most (1st) | 31 (27) | 229 (25) | 1.2 (0.7–2.2) | 0.46 |
B | ||||
Least (4th) | 23 (20) | 231 (25) | Reference | |
Most (1st) | 37 (32) | 231 (25) | 1.5 (0.9–2.7) | 0.23 |
C | ||||
Least (4th) | 30 (26) | 209 (23) | Reference | |
Most (1st) | 26 (22) | 227 (25) | 0.8 (0.4–1.4) | 0.19 |
HLA Class II | ||||
DPB1 | ||||
Least (4th) | 26 (22) | 220 (24) | Reference | |
Most (1st) | 19 (16) | 244 (27) | 0.7 (0.3–1.2) | 0.04 |
DQA1 | ||||
Least (4th) | 26 (22) | 218 (24) | Reference | |
Most (1st) | 19 (16) | 221 (24) | 0.7 (0.4–1.4) | 0.25 |
DQB1 | ||||
Least (4th) | 29 (25) | 295 (32) | Reference | |
Most (1st) | 18 (15) | 221 (24) | 0.8 (0.4–1.5) | 0.89 |
DRB1 | ||||
Least (4th) | 14 (12) | 210 (23) | Reference | |
Most (1st) | 28 (24) | 244 (27) | 1.7 (0.9–3.3) | 0.42 |