Table 3 Associations between IFNL4-rs368234815 and infections in 914 children from the Mali birth cohort study.

From: IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children

Infection

 

rs368234815 genotypes

rs368234815 alleles

Ever/nevera

Ever/never adjb

Total % of total

Total

TT/TT

TT/dG

dG/dG

TT

dG

OR

P value

OR

P value

n, %

n, %

n, %

n, %

n, %

n, %

914

77

373

464

527

1301

 

8.4

40.8

50.8

28.8

71.2

Malariac

Never

218

24

99

95

147

289

Ref

 

Ref

 

23.9

 

11.0

45.4

43.6

33.7

66.3

    

Any

696

53

274

369

380

1012

1.32 (1.04–1.68)

0.022

1.30 (1.02–1.65)

0.033

76.1

 

7.6

39.4

53.0

27.3

72.7

    

SM

102

4

44

54

52

152

1.53 (1.01–2.30)

0.044

1.48 (0.98–2.24)

0.061

11.2

 

3.9

43.1

52.9

25.5

74.5

    

NSM

594

49

230

315

328

860

1.30 (1.02–1.65)

0.035

1.28 (1.00–1.63)

0.047

65.0

 

8.3

38.7

53.0

27.6

72.4

    

GII

Never

109

16

49

44

81

137

Ref

 

Ref

 

11.9

 

14.7

45.0

40.4

37.2

62.8

    

Ever

805

61

324

420

446

1164

1.50 (1.11–2.03)

0.0079

1.53 (1.13–2.07)

0.0054

88.1

 

7.6

40.3

52.2

27.7

72.3

    

RI

Never

21

4

7

10

15

27

Ref

 

Ref

 

2.3

 

19.1

33.3

47.6

35.7

64.3

    

Ever

893

73

366

454

512

1274

1.20 (0.63–2.29)

0.58

1.20 (0.63–2.28)

0.58

97.7

 

8.2

41.0

50.8

28.7

71.3

    
  1. GII gastrointestinal infections, RI respiratory infections, any malaria positivity by blood smear test with/without additional clinical symptoms, SM severe malaria, NSM non-severe malaria, in bold - significant associations.
  2. aLogistic regression analysis based on additive genetic models and adjusting for the duration of follow-up (weeks).
  3. bAdditionally adjusting for tribes.
  4. cResults for malaria are also adjusted for HBB status.
Back to article page